Tetanus - Diphtheria Vaccine (Td)

Generic Name: Tetanus - Diphtheria Vaccine (Td)

Brand Names:

Availability: Available with Prescription

Drug Class: Vaccines, immunoglobulins and antisera

Indications

Prevention of tetanus in wound management
Prevention of tetanus and diphtheria in pregnant women or women of childbearing age
Prevention of tetanus and diphtheria in children over 4 years and adolescents (booster dose after complete primary vaccination)

Composition, forms, route of administration

Bivalent vaccine combining tetanus toxoid and diphtheria toxoid (containing reduced dose of diphtheria toxoid)
Suspension for injection in multidose vial, for IM injection into the deltoid muscle

Dosage and vaccination schedule

Child and adult: 0.5 ml per dose

Prevention of tetanus in wound management

Type of wound	Complete vaccination (3 or more doses) Time since administration of last dose			Incomplete vaccination (less than 3 doses) or no vaccination or unknown status
Type of wound	< 5 years	5-10 years	> 10 years
Minor, clean	None	None	Td 1 booster dose	Initiate(a) or complete tetanus vaccination
Other	None	Td 1 booster dose	Td 1 booster dose	Initiate(a) or complete tetanus vaccination and administer tetanus immunoglobulin

(a) 2 doses 4 weeks apart then3 additional doses administered according to the vaccination schedule below.

Prevention of tetanus in pregnant women and women of childbearing age

5 doses administered according to the schedule below:

Td1	On ﬁrst contact with the healthcare system or as soon as possible during pregnancy
Td2	At least 4 weeks afterTd1
Td3	6 months to 1 year after Td2 or during the following pregnancy
Td4	1 to 5 years after Td3 or during the following pregnancy
Td5	1 to 10 years after Td4 or during the following pregnancy

In pregnant women, administer at least 2 doses before delivery: the 1st dose as soon as possible during pregnancy and the 2nd dose at least 4 weeks after the 1st and at least 2 weeks before due date. After delivery, continue vaccination as described in the table above until the required 5 doses have been administered.

Prevention of tetanus in children over 4 years (after complete primary vaccination and 1st booster between 12 and 23 months)

Booster dose between 4 and 7 years then between 9 and 15 years

Contra-indications, adverse effects, precautions

Do not administer in the event of allergic reactions after a previous dose of tetanus or diphtheria vaccine.
Vaccination should be postponed in the event of severe acute febrile illness;minor infections are not contra-indications.
May cause: mild local reactions (redness,pain at the injection site), fever, pain, malaise; rarely:anaphylactic reactions.
If administered simultaneously with other vaccines,use different syringes and injection sites.
Pregnancy and breast-feeding: no contra-indication

Remarks

The monovalent tetanus (TT) vaccine is used in certain national protocols. Use perferably the conjugate tetanus-diphtheria (Td) vaccine for the prevention of tetanus in children over 7 years, adolescents and adults.
Tetanus vaccination in pregnant women and women of child bearing age protects neonates from tetanus.

Storage

– Between 2 °C and 8 °C. Do not freeze.