Treatment of uncomplicated falciparum malaria, in combination with artesunate
Treatment of uncomplicated malaria due to other Plasmodium species, in combination with artesunate, when chloroquine cannot be used
Completion treatment following parenteral therapy for severe malaria, in combination with artesunate
Forms and strengths
200 mg amodiaquine hydrochloride tablet, containing 153 mg amodiaquine base
Dosage and duration
Child and adult: 10 mg base/kg once daily for 3 days, in combination with artesunate
Contra-indications, adverse effects, precautions
Do not administer in the event of previous severe adverse reaction to treatment with amodiaquine (e.g. hypersensitivity reaction,hepatitis, leucopenia, agranulocytosis).
Do not administer to patients taking efavirenz.
May cause: gastrointestinal disturbances, pruritus, cough, insomnia.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication
Remarks
Also comes as co-packaged dispersible tablets for seasonal malaria chemoprevention in children: amodiaquine 153 mg + sulfadoxine/pyrimethamine 500 mg/25 mg and amodiaquine 76.5 mg + sulfadoxine/pyrimethamine 250 mg/12.5mg.